"We want to examine whether athletes may be more predisposed to injuries because of the functional changes in terms of their anatomy and physiology during the menstrual cycle," said Simon Augustus, senior lecturer in sport biomechanics at the university.
"We know hormones fluctuate during different phases of the cycle but we don't yet know how much of an influence that may have on the risk of injury."
Players from London clubs, including Fulham and Chelsea, as well as some in the grassroots game, will take part in the research by regularly having their blood and physical performance tested.
The research will track hormone concentrations through their menstrual cycles, particularly oestrogen and progesterone, with previous research suggesting they could be linked to increased ligament laxity and decreased neuromuscular reaction times.
Scenarios that commonly lead to ACL injuries, such as rapid directional changes and landing after heading the ball, will be analysed to see if there is a correlation with hormone levels.
"We know some injuries are unavoidable, but we're attempting to help those individuals who injure their ACL outside of impact actions. Those are the ones where we might have more chance to intervene and prevent them from taking place by utilising strength training or tweaking technique," Augustus said.
"There are so many different factors involved with ACL injuries. We are starting to research this from an individual approach and look at an athlete's whole profile and putting protocols in place to reduce risk."