Scheffler - who pipped Dechambeau to finish fourth behind McIlroy at the Masters - was utterly dominant in his hometown tournament last week, posting rounds of 61, 63, 66 and 63. His aggregate of 253 at TPC Craig Ranch equalled the PGA Tour record.
In claiming his 14th tour victory, the 28-year-old Texan was top in no fewer than 14 statistical categories. They included, strokes gained tee to green and approach, putting average, total birdies and scoring average on par three, four and five holes.
Scheffler was the complete package while securing his first win of 2025. It came in his final outing before the next major, the US PGA Championship which starts on 15 May.
Everything points to a determined response to McIlroy's feat of completing his full set of major titles when he succeeded Scheffler as Masters champion last month.
"I think we're all fired up to come out here and compete," Scheffler said.
"This week I was the best player. I have the week off, and we'll see the week after who is the best player at the PGA.
"Rory has been playing some tremendous golf this year. The career Grand Slam was really special to watch. I was glad to be able to be there for it.
"I think any time you're getting beat, you're always fired up just a little bit extra to go out and practice. I feel like my game is trending in a good direction. I'm excited to start the rest of the season."
DeChambeau, who faded when playing in the final group with McIlroy at Augusta three weeks ago, must be feeling similarly bullish. Closing round failures were beginning to pile up, not just with his 75 to finish tied fifth at Augusta.
The 31-year-old squandered opportunities at Doral in early April and again last week at the LIV event in Mexico. The strength of the 54-hole, limited field breakaway tour is often questioned, but winning is a handy habit regardless.
And DeChambeau has proved his major credentials while playing LIV's limited schedule. He was a close runner-up to Xander Schauffele at last year's US PGA, before overhauling a faltering McIlroy to win the US Open at Pinehurst last June.
"There's a lot of star-studded talent out there right now that's going to be in the PGA Championship," DeChambeau observed. "We're going to be battling it out."
The Texas-based Californian added: "There's a lot more work to be done this year. There are three more majors, and my eyes are focused on that with all the other LIV events, doing my absolute best in every single event I show up to."