Major League Cricket (MLC) chief executive Johnny Grave says the tournament should not be seen as a danger to The Hundred any more.
The third edition of the United States' franchise league starts on Friday at 02:00 BST when defending champions Washington Freedom face San Francisco Unicorns.
MLC's emergence caused some uneasiness in English cricket with fears a clash with The Hundred would create a scramble for the best English and overseas players.
However, relations between the England and Wales Cricket Board (ECB) and MLC have improved with both parties keen to work together so the tournaments do not overlap where possible.
A number of American investors - including some with interests in MLC - are in the process of finalising deals to acquire stakes in franchise in The Hundred following the ECB sale earlier this year.
"The likes of England and Australia and India have had complete monopolies and global dominance," Grave told BBC Sport.
"There's always a bit of emotional threat from anything that's new that could destabilise what's been before.
"But I think now the relationship and communication with the ECB is great. Certainly, I don't think we [MLC] are a threat to the ECB."