Robert Sanchez, Chelsea, keeper, £4.5m - Everton (h)
Visitors Everton only have four goals in their past six games and their 10 big chances is the third lowest in the league.
Trent Alexander-Arnold, Liverpool, £7.2m - Tottenham (h)
This might be one of the last times we can pick maybe the greatest FPL defensive asset of all time - if rumours of a summer move to Real Madrid are true.
Alexander-Arnold has only started 26 games this season but is still the top-scoring FPL defender.
Liverpool could easily keep Spurs from scoring - especially if their focus is on the Europa League semi-final they have four days later - and his attacking potential is off the charts.
Marc Cucurella, Chelsea, £5.4m - Everton (h)
Everton at home is a great FPL match-up for Chelsea assets, but which forward players can you rely on? Cole Palmer and Nicolas Jackson are out of form and every other one is a minutes risk.
Step forward Cucurella. Boss Enzo Maresca joked about the Spaniard's scoring prowess last week and Chelsea have needed him this season, with six goals in all competitions.
He is the club's fifth top scorer in the Premier League.
The goals have dried up for Everton so this is a simple form-plus-fixtures pick.
Ryan Sessegnon, Fulham, £4.1m - Southampton (a)
A budget defender playing OOP (Out of position) as a wide forward against the league's lowest-scoring team?
Sessegnon has started Fulham's past three and been productive too.
In his past seven games - only four of them starts - the 24-year-old has three goals and two assists. In that time, only forward Rodrigo Muniz has more shots, big chances and goals for Fulham.
He's also had more shots than any other defender in the league in that time.
Rayan Ait-Nouri, Wolves, £5m - Leicester (h)
Another cheap, high-upside defender with a great chance of a clean sheet against Leicester's turgid attack - as well as attacking-haul potential.
Ait-Nouri gets into such attacking positions and his statistics back that up.
Only Manchester City's Josko Gvardiol has scored more goals and he is joint third for shots in the box.